Institute of Biology II
Department for Zoology and Animal Physiology
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Mechanisms of binaural remodeling in the midbrain

The inferior colliculus (IC) is the most important integrative center in the brainstem. It receives input from Nucleus laminaris. The IC sends its information via a midbrain pathway to the optic tectum and via a forebrain pathway to the auditory arcopallium (Figure). We found that across-frequency integration a loss of low frequencies in the midbrain pathway leads to an unambiguous representation of ITD (Figure). Thus, ITD is remodeled in the midbrain pathway for precise sound localization.


Original Publications

Asadollahi A, Endler F, Nelken I, Wagner H. (2010) Neural correlates of binaural masking level difference in the inferior colliculus of the barn owl (Tyto alba). Eur J Neurosci.32: 606-618.

Wagner H, Asadollahi A, Bremen P, Endler F, Vonderschen K, von Campenhausen M (2007) Distribution of interaural time difference in the barn owl's inferior colliculus in the low- and high-frequency ranges. J Neurosci 27: 4191-4200.

Bremen P, Poganiatz I, von Campenhausen M, Wagner H (2007) Sensitivity to interaural time difference and representation of azimuth in central nucleus of inferior colliculus in the barn owl. J Comp Physiol A193: 99-112.

Nieder B, Wagner H, Luksch H (2003) Development of output connections from the ICX to the optic tectum in barn owls. J. comp. Neurol. 464: 511-524.

Wagner H, Güntürkün O and Nieder B (2003) Anatomical markers for the subdivisions of the barn owl's inferior-collicular complex and adjacent peri- and subventricular structures. J. comp. Neurol. 465: 145-159.

Wagner H, v. Campenhausen M (2002) Distribution of auditory motion-direction sensitive neurons in the barn owl's midbrain. J. comp. Physiol. A188: 705-713

Wagner H, Mazer JA and von Campenhausen M (2002) Response properties of neurons in the core of the central nucleus of the inferior colliculus of the barn owl. Europ J Neurosci 15: 1343-1352.

Luksch H, Gauger B and Wagner H (2000) A candidate pathway for a visual instructional signal to the barn owl's auditory system. J. Neurosci, 20: RC70 (1-4)

Kubke F, Gauger B, Basu L, Wagner H and Carr CE (1999) Development of calretinin immunoreactivity in the brainstem auditory nuclei of the barn owl (Tyto alba). J. comp. Neurol. 415: 189-203.

Wagner H (1993) Lesion-induced sound-localization deficits in the barn owl. J Neurosci 13: 371-386.

Wagner H (1992) On the ability of neurons in the barn owl's inferior colliculus to sense brief appearances of interaural time difference. J Comp Physiol A170: 3-11.

Wagner H (1990) Receptive fields of neurons in the owl's auditory brainstem change dynamically. Europ J Neurosci 2: 949-959.

Takahashi TT, Wagner H, and Konishi M (1989) Role of commissural projections in the representation of bilateral auditory space in the barn owl's inferior colliculus. J Comp Neurol 281: 545-554.

Wagner H, Takahashi T and Konishi M (1987) Representation of interaural time difference in the central nucleus of the barn owl's inferior colliculus. J. Neurosci 7: 3105-3116.